LONDON — Prime Minister Boris Johnson had been expected to trumpet a rare success in the campaign against the coronavirus on Friday: news that Britain had vaccinated 5.4 million people. By the end of the day, it was overtaken by a tentative finding that a new variant of the virus may be deadlier than the original.

That possibility, raised by preliminary studies relying on small numbers of deaths in hard-hit hospitals, remains far from conclusive. But the prospect that the fast-spreading new variant, already known to be more contagious, could also be more lethal compounded fears that even with the arrival of vaccines, the pandemic will remain a severe threat for some time.

Government scientists said the early evidence suggests that the new variant, first detected late last year in Britain, could raise the risk of death by some 30 percent. But even with such an increase, the great majority of cases are not fatal, and the government estimates included a broad range of possible effects.

“In addition to spreading more quickly,” Mr. Johnson said at a Downing Street news conference, “it also now appears that there is some evidence that the new variant — the variant that was first identified in London and the southeast — may be associated with a higher degree of mortality.”

The underlying evidence, outlined in a report published on Friday by a government scientific committee, was less emphatic than the prime minister, saying only that there was a “realistic possibility” that the new variant was deadlier and outlining a number of inescapable limitations in the data.

“I want to stress that there’s a lot of uncertainty around these numbers and we need more work to get a precise handle on it, but it obviously is a concern that this has an increase in mortality as well as an increase in transmissibility,” said the government’s chief scientific adviser, Sir Patrick Vallance.

For Mr. Johnson, who has struggled to find a silver lining in Britain’s response to the virus, it was not the first time that good news and bad went hand in hand. On Dec. 30, the government announced the authorization of a homegrown vaccine, developed by the University of Oxford and AstraZeneca, only to put much of the country into a stricter lockdown hours later because of a surge in infections.

Britain’s struggle with the pandemic has increasingly become a race between vaccinating the public and confronting mutations in the virus, like the new variant that now accounts for a significant percentage of new cases around the country. It is a pitched battle that scientists say evokes hope as well as anxiety.

“2021 is going to be a cat-and-mouse game to see if we can vaccinate people quickly enough to stay ahead of the variants,” said Devi Sridhar, director of the global public health program at the University of Edinburgh.

Outside experts said that the early claims of higher mortality were far from resolved.

For one, the studies were based on a small subset — roughly 8 percent — of total deaths in Britain, raising the possibility that the results “may therefore not be representative of the total population,” the report said.

For another, less than 3 percent of known infections in Britain have been fatal, so the new variant’s effect on mortality would have been measured in relatively small numbers, making it harder to pinpoint with certainty.

Moreover, the signs of higher mortality rates were at odds with evidence suggesting that people with the new variant were no more likely to be hospitalized than those infected with better-established ones.

Covid-19 Vaccines ›

Answers to Your Vaccine Questions

While the exact order of vaccine recipients may vary by state, most will likely put medical workers and residents of long-term care facilities first. If you want to understand how this decision is getting made, this article will help.

Life will return to normal only when society as a whole gains enough protection against the coronavirus. Once countries authorize a vaccine, they’ll only be able to vaccinate a few percent of their citizens at most in the first couple months. The unvaccinated majority will still remain vulnerable to getting infected. A growing number of coronavirus vaccines are showing robust protection against becoming sick. But it’s also possible for people to spread the virus without even knowing they’re infected because they experience only mild symptoms or none at all. Scientists don’t yet know if the vaccines also block the transmission of the coronavirus. So for the time being, even vaccinated people will need to wear masks, avoid indoor crowds, and so on. Once enough people get vaccinated, it will become very difficult for the coronavirus to find vulnerable people to infect. Depending on how quickly we as a society achieve that goal, life might start approaching something like normal by the fall 2021.

Yes, but not forever. The two vaccines that will potentially get authorized this month clearly protect people from getting sick with Covid-19. But the clinical trials that delivered these results were not designed to determine whether vaccinated people could still spread the coronavirus without developing symptoms. That remains a possibility. We know that people who are naturally infected by the coronavirus can spread it while they’re not experiencing any cough or other symptoms. Researchers will be intensely studying this question as the vaccines roll out. In the meantime, even vaccinated people will need to think of themselves as possible spreaders.

The Pfizer and BioNTech vaccine is delivered as a shot in the arm, like other typical vaccines. The injection won’t be any different from ones you’ve gotten before. Tens of thousands of people have already received the vaccines, and none of them have reported any serious health problems. But some of them have felt short-lived discomfort, including aches and flu-like symptoms that typically last a day. It’s possible that people may need to plan to take a day off work or school after the second shot. While these experiences aren’t pleasant, they are a good sign: they are the result of your own immune system encountering the vaccine and mounting a potent response that will provide long-lasting immunity.

No. The vaccines from Moderna and Pfizer use a genetic molecule to prime the immune system. That molecule, known as mRNA, is eventually destroyed by the body. The mRNA is packaged in an oily bubble that can fuse to a cell, allowing the molecule to slip in. The cell uses the mRNA to make proteins from the coronavirus, which can stimulate the immune system. At any moment, each of our cells may contain hundreds of thousands of mRNA molecules, which they produce in order to make proteins of their own. Once those proteins are made, our cells then shred the mRNA with special enzymes. The mRNA molecules our cells make can only survive a matter of minutes. The mRNA in vaccines is engineered to withstand the cell’s enzymes a bit longer, so that the cells can make extra virus proteins and prompt a stronger immune response. But the mRNA can only last for a few days at most before they are destroyed.

Beyond that, scientists said that any number of confounding factors — like hospitals being overrun or the variant potentially spreading more aggressively in settings like nursing homes — made it difficult to know for certain whether it was, in fact, any deadlier.

“We need more information before jumping to firm conclusions,” said Lawrence Young, a virologist at Warwick Medical School.

Ian Jones, a professor of virology at the University of Reading, noted that the report was “at pains to stress that the data is limited and the conclusions preliminary.” But, he added, “an increased case fatality rate is certainly possible with a virus that has upped its game in transmission.”

The scientific studies that the government relied on have not been published in full, and they described a broad range of possible effects of the new variant on mortality rates.

The report stressed that “the absolute risk of death per infection remains low.” And whatever the fatality rate, scientists said the best answer to the new variant had not changed: lockdowns, face coverings and vaccines.

Britain had injected more than 400,000 people in the previous 24 hours, keeping it on track to achieve Mr. Johnson’s goal of inoculating 15 million vulnerable people, almost a quarter of the population, by mid-February. On a per-capita basis, only Israel, the United Arab Emirates and Bahrain have done more. The United States and China have delivered more doses than Britain but to a smaller percentage of their populations.

Mr. Vallance said there was no evidence that the vaccines being deployed were not effective against the variant first identified in Britain. But he expressed less certainty about whether they offered similar protection against variants that originated in South Africa and Brazil.

The warnings about the variant captured the political crosswinds that Mr. Johnson has faced in responding to the pandemic. The rapid vaccine rollout will likely embolden members of his Conservative Party to renew their calls on him to begin easing the lockdown. But scientists warn that a full-scale easing of restrictions, even after widespread vaccinations, could ignite a fresh surge of infections.

The opposition Labour Party, meanwhile, criticized Mr. Johnson for springing yet another unwelcome surprise on the British public.

“This is deeply alarming news, not least because Boris Johnson assured the nation back in December there was no evidence the variant was more dangerous,” Jonathan Ashworth, the Labour Party’s shadow health secretary, said in statement.

Mr. Johnson presented the news as evidence of his commitment to present changing scientific evidence to the public. He also pleaded for people to stick to social distancing rules even as the vaccines promised a brighter future.

The warnings about the variant — first disclosed by a prominent epidemiologist, Neil Ferguson, in a statement on Friday to a well-connected television correspondent, Robert Peston — gave the prime minister grist for that cautionary message.

“We really can’t begin considering unlocking until we’re confident the vaccination program is working,” Mr. Johnson said. “We’ve got to get those rates of infection down.”

Source: Read Full Article