Victoria's second COVID-19 wave has officially ended after a man in his 90s was discharged from hospital on Monday, leaving the state with no active cases for the first time in almost nine months.

Monash Health confirmed the man, who has been treated at Monash Medical Centre for more than three weeks alongside his wife, was discharged on Monday evening.

"It's a wonderful news story, not just for the team looking after them at Monash but for the whole state," Monash Infectious Diseases Physician Rhonda Stuart told radio station 3AW.

The man and his wife – hospitalised since November 1 – were the last two remaining active cases in the state until the woman in her 80s was discharged from hospital on Thursday.

The couple both fell ill with the disease in early October, and have pulled through after serious battle with the virus, Dr Stuart said.

"They both had a stormy course really.. [but] they made it through and did really well," she said.

Monash Health was able to secure an exemption from state authorities to allow the couple's daughter to visit them in hospital during the darker stages of their battle with the virus.

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