The Left Wing: The panel discuss Joe Schmidt's many changes ahead of Saturday's warm-up clash against Wales

After Ireland’s record defeat to England at Twickenham, Joe Schmidt has picked his team for the redemption mission against Wales in Cardiff.

The Left Wing podcast panel of Cian Tracey, Ruaidhri O’Connor and Jonathan Bradley look at his back-row selection, the role of Will Addison and Rory Best’s captaincy as the World Cup looms large.

JetBlue’s stock drops after unit revenue guidance cut, citing disappointing demand trends

Shares of JetBlue Airways Corp. JBLU, -0.87% fell 3.3% in premarket trading Wednesday, after the air carrier cut its unit revenue outlook, citing weaker than expected demand trends across the system. The company now expects third-quarter revenue per available seat mile (RASM) growth of negative 2.0% to flat, compared with the previous guidance range of up 0.5% to up 3.5%. JetBlue said the decrease in RASM guidance is also a reflection of softer booking to Puerto Rico and includes a preliminary forecasted impact of Hurricane Dorian. The stock has lost 3.6% over the past three months through Tuesday, while the NYSE Arca Airline Index XAL, -1.22% has lost 7.0% and the S&P 500 SPX, -0.69% has gained 3.7%.

Nanogold Treatment In The Making For Prostate Cancer

Prostate cancer is one of the most common cancers in men. Studies have shown that 1 in 9 men on average, is diagnosed with prostate cancer during his lifetime.

A first-in-human trial, which evaluated Nanospectra Biosciences’ investigational device AuroLase in men with low-to-intermediate grade tumors within the prostate, has yielded positive results.

The AuroLase therapy involves intravenous administration of laser-excited gold-silica nanoparticles, called AuroShells. These AuroShells get accumulated within the solid tumor tissue when administered and the tumor is illuminated with a near-infrared laser. When exposed to the laser, these nanoparticles were able to ablate tumor tissues in a controlled manner, causing only minimum side effects.

If all goes well as planned, the company hopes to gain FDA clearance for its AuroLase device by the middle of 2021.

Let’s take a look at the drugs that passed muster with the FDA in August 2019.

Cathay Pacific says Chairman John Slosar resigns

Hong Kong's Cathay Pacific Airways said on Wednesday that its Chairman John Slosar had resigned from the board and will be replaced by Patrick Healy, a long-time executive at the airline's top shareholder Swire Pacific Ltd.

The resignation and appointment will take effect at Cathay's annual meeting on Nov 6, the carrier said in a statement.

Slosar's resignation follows the departure of CEO Rupert Hogg last month, after the Chinese aviation regulator increased scrutiny on the airline and its staff members following anti-government protests in Hong Kong.

Carolina Panthers QB Cam Newton sets Guinness world record for one-handed catches

Cam Newton has written himself into the record books — The Guinness Book of World Records. 

The Carolina Panthers quarterback caught 51 passes one-handed in a span of 60 seconds from Candler Hallow, a member of YouTube star MrBeast's crew, who were at Bank of America Stadium in July to help Newton set the record. Cleveland Browns wide receiver Jarvis Landry and former NFL quarterback Brady Quinn previously held the Guinness record with 48 one-handed catches in a minute. 

Newton has touted his hands as among the best in the league since being drafted in 2011. There was some controversy over whether some of his receptions counted since he trapped the ball against his body, but he still secured enough to stand atop the list alone. 

"That is going up in my house, man," Newton said when he received a plaque commemorating the record. 

"I wouldn't have been able to do that without my quarterback,'' Newton added. "I just feel like we have a bond for the rest of our life. Like Jack and Rose." 

The video showed Newton setting a pair of other records. He threw an underhand pass 39 yards to a different member of MrBeast's team, Garrett Niconienko, setting a new mark for the longest catch between the legs.

Newton also completed a 24-yard toss with a blindfolded Hallow to set the record for longest pass to a blindfolded, moving target. 

New US gun law may allow firearm seizures

National inaction has moved individual states to push forward with their own gun laws.

New laws that allow guns to be temporarily seized from dangerous owners are spreading across the United States.

The so-called “red flag” laws are now in 17 states, with more looking to follow.

Al Jazeera’s Alan Fisher reports from Maryland.

Roku stock gains after D.A. Davidson ups target to a new Street high

Roku Inc. shares ROKU, +3.65% are up 2.2% in premarket trading Wednesday after D.A. Davidson analyst Tom Forte raised his price target on the stock to $185 from $135. The new target is the highest listed on FactSet. Forte sees Roku as one of the companies best positioned to take advantage of the shift to over-the-top television from linear programming. He has increasing conviction in the company’s ability to "exploit the billions being spent across the industry on proprietary content" and make strides internationally. Shares have surged 412% so far this year, while the S&P 500 SPX, -0.69% has risen 16%.

American Eagle shares slide premarket after earnings beat offset by soft guidance

American Eagle Outfitters Inc. shares AEO, -3.27% slid about 3% in premarket trade Wednesday, after the clothing retailer beat estimates for its fiscal second quarter but offered soft guidance. Pittsburgh-based American Eagle said it had net income of $64.9 million, or 38 cents a share, in the quarter to Aug. 4, up from $60.3 million, or 34 cents a share, in the year-earlier period. Adjusted per-share earnings came to 39 cents, ahead of the 32 cents FactSet consensus. Revenue rose to $1.04 billion from $965 million, also ahead of the $1.01 billion FactSet consensus. Same-store sales rose 2%, below the 3% FactSet consensus. Chief Executive Jay Schottenstein said the company was disappointed to post operating results that lagged its expectations. "We faced challenges largely stemming from underperformance in certain seasonal categories and a delayed start to back-to-school," he said in a statement. The company is now expecting third-quarter same-store sales to rise in the low to mid single digits, while EPS is forecast at about 47 cents to 49 cents. The FactSet consensus is for same-store sales growth of 3.8% and EPS of 52 cents. Shares have fallen 16% in 2019, while the S&P 500 SPX, -0.69% has gained 16%.