Friday, 4 Oct 2024

LogicBio Therapeutics’ Phase 1/2 SUNRISE Trial Of LB-001 Placed On Clinical Hold

Imperial Oil Ltd Q4 Earnings Summary

Below are the earnings highlights for Imperial Oil Ltd (IMO.TO):

Earnings: C$0.81 billion in Q4 vs. -C$1.15 billion in the same period last year.
EPS: C$1.18 in Q4 vs. -C$1.56 in the same period last year.
Revenue: C$12.31 billion in Q4 vs. C$6.03 billion in the same period last year.

WhatpsApp DOWN – panic as messaging service not working in UK and across world

SOCIAL media users are facing a black out this evening as WhatsApp crashes across the world.

The popular messaging app has gone down in the UK and parts of Europe as well as the US and South America, according to website Down Detector.

In the UK, Londoners in particular were found to be having problems sending messages this evening.

Whatsapp users around the world took to Twitter to vent their frustration with many panicking that they would be kept in the dark all night.

One user wrote: "Seems as tho WhatsApp is down? Says 'please try again later' when refreshing my contact list."


Posting a meme, and a sentence with crying eyes emoji another tweeted: "WhatsApp is down"

One worried Whatsapp user posted: "WhatsApp down in Mumbai, India!????"

The outage comes days after it emerged WhatsApp will start deleting certain messages, photos and videos that you'd saved as part of a new app update.

KYOCERA 9-month Profit Rises; Sales Revenue Up 23.2% – Quick Facts

KYOCERA Corp. (KYO) reported profit to owners of parent of 119.8 billion yen for the nine months ended December 31, 2021, up 87.4 percent from last year. Basic earnings per share was 331.34 yen compared to 176.39 yen.

For the nine month period, sales revenue was 1.36 trillion yen, an increase of 23.2 percent from last year.

For the year ending March 31, 2022, the company projects: basic earnings per share of 384.34 yen; and sales revenue of 1.75 trillion yen.

Sirius XM Posts Profit In Q4, Issues New 2022 Guidance; Declares Special Cash Dividend

Sirius XM Holdings Inc. (SIRI) reported fourth quarter net income of $318 million or $0.08 per share compared to a loss of $677 million or $0.16 per share, prior year. The company noted that its prior year fourth quarter was impacted by a $976 million non-cash impairment charge associated with Pandora.

On average, 14 analysts polled by Thomson Reuters expected the company to report profit per share of $0.07, for the quarter. Analysts’ estimates typically exclude special items.

Revenue increased to $2.28 billion from $2.19 billion, a year ago. Analysts on average had estimated $2.25 billion in revenue.

For full year 2022, the company projects: SiriusXM self-pay net subscriber additions of approximately 500,000; total revenue of approximately $9.0 billion; adjusted EBITDA of approximately $2.8 billion; and free cash flow of approximately $1.55 billion.

SiriusXM also said its Board declared a special cash dividend of $0.25 per share, payable on February 25, 2022, to stockholders of record as of the close of business on February 11, 2022. The total amount of the special cash dividend is expected to be approximately $1 billion.

As of January 28, 2022, the company had approximately $2.0 billion of remaining share repurchase authorization.

'It's insane': Gas station owner reveals what inflation is doing to his business

New York (CNN Business)A key measure of inflation rose 5.8% between December 2020 and December 2021, the Bureau of Economic Analysis reported Friday.

It was the biggest advance since 1982.
Energy prices alone rose nearly 30% over the course of 2021, while food prices climbed 5.7%.

    Stripping out those two components, the core consumer price index — which is the Federal Reserve’s preferred measure of inflation — rose 4.9% in the 12 months to December. That was the fastest price hike by that measure since 1983.

      For the month of December alone, prices rose 0.4% — a decline from the 0.6% in both October and November. Core prices advanced 0.5%, the same amount as in November.

      While prices rose, so did American incomes — albeit at a slower pace. Personal incomes increased by 0.3%, or $70.7 billion in December, while disposable incomes increased only 0.2%, or $49.9 billion.
      Americans also spent less in December, and consumer spending actually declined for the first time in months.

        Retailers had warned customers of supply chain disruptions and shortages, effectively pulling the holiday shopping season into November.
        This is a developing story. It will be updated

        LogicBio Therapeutics’ Phase 1/2 SUNRISE Trial Of LB-001 Placed On Clinical Hold

        LogicBio Therapeutics, Inc. (LOGC) said FDA has notified the company that its phase 1/2 SUNRISE trial of LB-001 in pediatric patients with methylmalonic acidemia has been placed on clinical hold. The company noted that, until it has more clarity regarding the impact of the clinical hold, LogicBio is suspending guidance on the timing of announcing interim data for the SUNRISE trial.

        In January 2022, the fourth patient dosed in the SUNRISE trial experienced a drug-related serious adverse event, which was categorized as a case of thrombotic microangiopathy. As a result, the FDA notified the company that the SUNRISE trial has been placed on clinical hold.

        LogicBio said it will be working closely with the FDA and the Data Safety Monitoring Board for the trial to determine the next steps for the SUNRISE trial and the LB-001 program.

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