WASHINGTON (AP) — Federal health officials issued a national warning Thursday against marijuana use by adolescents and pregnant women, as more states legalize the increasingly potent drug for medicinal and recreational use.

Health and Human Services Secretary Alex Azar and Surgeon General Jerome Adams made the announcement, with Azar calling marijuana “a dangerous drug.” Officials said President Donald Trump has donated $100,000 — one-quarter of his annual government salary — toward a digital campaign to raise awareness of the risks. Trump has forgone his official salary since taking office.

The warning comes as legal marijuana has grown into a $10-billion industry in the U.S. with nearly two-thirds of states legalizing it, mainly for medical uses.

Possessing small amounts of marijuana for adult recreational use is legal in 11 states and the District of Columbia, according to the National Conference of State Legislatures. The list includes California, Colorado, Michigan and Maine. Federal law still treats it as a controlled substance akin to opioids.

Adams said science shows that marijuana is harmful to the developing brains of teenagers and to the human fetus. The drug has also gotten stronger, with a three-fold increase in the concentration of the active ingredient THC in cultivated plants over the last 20 years.

“This ain’t your mother’s marijuana,” Adams said.

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11 PHOTOSSisters of the Valley 'weed nuns' sell marijuana onlineSee GallerySisters of the Valley 'weed nuns' sell marijuana onlineCalifornia "weed nun" India Delgado, who goes by the name Sister Eevee, trims hemp in the kitchen at Sisters of the Valley near Merced, California, U.S., April 18, 2017. Picture taken April 18, 2017. REUTERS/Lucy NicholsonCalifornia “weed nun” Christine Meeusen, 57, who goes by the name Sister Kate (R), and Desiree Calderon, who goes by the name Sister Freya, pour CBD salve made from hemp at Sisters of the Valley near Merced, California, U.S., April 18, 2017. Picture taken April 18, 2017. REUTERS/Lucy NicholsonCalifornia “weed nun” Christine Meeusen, 57, who goes by the name Sister Kate, opens a bag of hemp in the kitchen at Sisters of the Valley near Merced, California, U.S., April 18, 2017. Picture taken April 18, 2017. REUTERS/Lucy NicholsonHemp is seen in bags at Sisters of the Valley near Merced, California, U.S., April 18, 2017. Picture taken April 18, 2017. REUTERS/Lucy NicholsonCalifornia “weed nun” Christine Meeusen, 57, who goes by the name Sister Kate (L), and India Delgado, who goes by the name Sister Eevee, trim hemp in the kitchen at Sisters of the Valley near Merced, California, U.S., April 18, 2017. Picture taken April 18, 2017. REUTERS/Lucy NicholsonCalifornia “weed nun” Desiree Calderon, who goes by the name Sister Freya, pours CBD salve made from hemp at Sisters of the Valley near Merced, California, U.S., April 18, 2017. Picture taken April 18, 2017. REUTERS/Lucy NicholsonHemp lies on the kitchen table at Sisters of the Valley near Merced, California, U.S., April 18, 2017. Picture taken April 18, 2017. REUTERS/Lucy NicholsonCalifornia “weed nun” Desiree Calderon, who goes by the name Sister Freya, trims hemp in the kitchen at Sisters of the Valley near Merced, California, U.S., April 18, 2017. Picture taken April 18, 2017. REUTERS/Lucy NicholsonCalifornia “weed nun” Christine Meeusen, 57, walks to the hemp drying room at Sisters of the Valley near Merced, California, U.S., April 18, 2017. Picture taken April 18, 2017. REUTERS/Lucy NicholsonHemp is seen in the refrigerator at Sisters of the Valley near Merced, California, U.S., April 18, 2017. Picture taken April 18, 2017. REUTERS/Lucy NicholsonCalifornia “weed nun” Christine Meeusen, 57, who goes by the name Sister Kate, holds hemp in the kitchen at Sisters of the Valley near Merced, California, U.S., April 18, 2017. Picture taken April 18, 2017. REUTERS/Lucy NicholsonUp Next

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The surgeon general said his advisory is a direct result of scientific research that runs counter to changing social mores.

“Marijuana use is a risk to the developing brain,” Adams said. “Over time there has been a change in attitudes about marijuana creating a false sense of security.”

While the White House has made the opioid epidemic a top policy and political priority, marijuana previously had not gotten such high-level attention.

Federal officials say they fear the trend toward legalization may make it more enticing for teenagers to try marijuana. It’s a commonly used drug among youths, they said, along with alcohol and e-cigarettes. No states allow recreational marijuana use by teens. States with medical marijuana programs, Illinois among them, generally allow use by minors with consent from a legal guardian and certification from a doctor.

Adams said that for teens it carries a risk of affecting brain development, which continues in the 20s. Frequent marijuana use by teenagers is associated with changes in parts of the brain that are involved with attention, memory, decision-making and motivation.

Among pregnant women, marijuana is the most commonly used illicit drug, with about 7% reporting they had used it within the past month in a 2017 study. The American College of Obstetricians and Gynecologists and the American Academy of Pediatrics advise women not to use marijuana during pregnancy, and to discontinue the drug if they find out they are pregnant.

HHS Assistant Secretary for Health Brett Giroir said pregnant women taking marijuana to relieve morning sickness should stop. “If you have morning sickness, talk to your physician,” he said.

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