Vaccines are here, bringing hope of the pandemic’s end. But even when you get your dose, it won’t mean an immediate return to life as you knew it.

Scientists cite several reasons for staying masked and cautious as you start your post-vaccine life. Vaccines don’t offer perfect protection; we don’t yet know whether vaccinated people can spread the virus; and coronavirus is likely to continue its rapid spread until a large majority of people is vaccinated or has survived a natural infection.

Because vaccines will not be a ticket back to 2019, Uma Karmarkar, a neuroeconomist at the University of California, San Diego, recommends that people think about “how we are moving forward” instead of “getting back to normal.” (Neuroeconomics bridges neuroscience, psychology and economics.)

Vaccination provides you and society the best way to move forward. Some parts of life will begin to feel different as soon as the vaccine kicks in. Other changes will take longer. When it comes to thinking about what’s safe, it may help to think of post-vaccine life in several phases.

What’s safer to do once I’m vaccinated?

When people are fully vaccinated (a week or two after the second dose), but most others aren’t yet, their lives probably shouldn’t change very much, experts say. It will most likely be safer for them to do things like visit the grocery store or the post office. But vaccinated people should still wear masks and avoid large groups and indoor gatherings.

That’s important for both their health and the health of others, experts said. Scientists are waiting to learn if vaccinated people can spread the virus to others. (Early data on transmission seems promising, but vaccines are very unlikely to curb contagiousness entirely.) Also, while early evidence suggests that the first vaccines in the U.S. reduce people’s risk of developing Covid-19 by around 95 percent, that still means a small fraction could get sick — and as long as the virus is as widespread as it is now, even that small share could be a big number.

“Five percent of a really high number is still a high number, and what you want is 5 percent of a relatively medium or low number,” said Dr. Ashish Jha, a physician and the dean of the School of Public Health at Brown.

In an informal survey of 700 epidemiologists by The New York Times, less than a third said they would change their behavior after they were vaccinated; half said they would wait until at least 70 percent of the population was vaccinated.

Kelsey Vandersteen, a trauma I.C.U. nurse at UW Health University Hospital in Madison, Wis., will receive her first injection on Wednesday — probably months ahead of her young daughters and husband, who works from home for a software company.

Even after her second shot, she doesn’t intend to change her behavior, including wearing a mask. She says she hopes this will model good behavior for others. Besides, she said: “I prefer the mask. It protects me from other stuff as well. We’ve been completely healthy — not a sniffle since March.”

What’s safer to do once my friends and family are vaccinated?

If you and the people you want to see are all vaccinated, it should be safer to socialize with them, including indoors, experts said. But being in large groups or traveling, when there’s no way to know if the people around you have been vaccinated, will remain risky, they said.

Eric Lofgren, an infectious disease epidemiologist at Washington State University, said at that point, he would restart in-person board game nights and one-on-one meetings with students, but he wouldn’t fly on vacation or go to a movie theater.

“Immunity is not an on/off switch; it’s a dial,” he said. “If you’re below herd immunity, the virus is still happily circulating in the population and there’s always a chance the vaccine isn’t working for you.”

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Answers to Your Vaccine Questions

With distribution of a coronavirus vaccine beginning in the U.S., here are answers to some questions you may be wondering about:

• • If I live in the U.S., when can I get the vaccine? While the exact order of vaccine recipients may vary by state, most will likely put medical workers and residents of long-term care facilities first. If you want to understand how this decision is getting made, this article will help.
  • When can I return to normal life after being vaccinated? Life will return to normal only when society as a whole gains enough protection against the coronavirus. Once countries authorize a vaccine, they’ll only be able to vaccinate a few percent of their citizens at most in the first couple months. The unvaccinated majority will still remain vulnerable to getting infected. A growing number of coronavirus vaccines are showing robust protection against becoming sick. But it’s also possible for people to spread the virus without even knowing they’re infected because they experience only mild symptoms or none at all. Scientists don’t yet know if the vaccines also block the transmission of the coronavirus. So for the time being, even vaccinated people will need to wear masks, avoid indoor crowds, and so on. Once enough people get vaccinated, it will become very difficult for the coronavirus to find vulnerable people to infect. Depending on how quickly we as a society achieve that goal, life might start approaching something like normal by the fall 2021.
  • If I’ve been vaccinated, do I still need to wear a mask? Yes, but not forever. Here’s why. The coronavirus vaccines are injected deep into the muscles and stimulate the immune system to produce antibodies. This appears to be enough protection to keep the vaccinated person from getting ill. But what’s not clear is whether it’s possible for the virus to bloom in the nose — and be sneezed or breathed out to infect others — even as antibodies elsewhere in the body have mobilized to prevent the vaccinated person from getting sick. The vaccine clinical trials were designed to determine whether vaccinated people are protected from illness — not to find out whether they could still spread the coronavirus. Based on studies of flu vaccine and even patients infected with Covid-19, researchers have reason to be hopeful that vaccinated people won’t spread the virus, but more research is needed. In the meantime, everyone — even vaccinated people — will need to think of themselves as possible silent spreaders and keep wearing a mask. Read more here.
  • Will it hurt? What are the side effects? The Pfizer and BioNTech vaccine is delivered as a shot in the arm, like other typical vaccines. The injection into your arm won’t feel different than any other vaccine, but the rate of short-lived side effects does appear higher than a flu shot. Tens of thousands of people have already received the vaccines, and none of them have reported any serious health problems. The side effects, which can resemble the symptoms of Covid-19, last about a day and appear more likely after the second dose. Early reports from vaccine trials suggest some people might need to take a day off from work because they feel lousy after receiving the second dose. In the Pfizer study, about half developed fatigue. Other side effects occurred in at least 25 to 33 percent of patients, sometimes more, including headaches, chills and muscle pain. While these experiences aren’t pleasant, they are a good sign that your own immune system is mounting a potent response to the vaccine that will provide long-lasting immunity.
  • Will mRNA vaccines change my genes? No. The vaccines from Moderna and Pfizer use a genetic molecule to prime the immune system. That molecule, known as mRNA, is eventually destroyed by the body. The mRNA is packaged in an oily bubble that can fuse to a cell, allowing the molecule to slip in. The cell uses the mRNA to make proteins from the coronavirus, which can stimulate the immune system. At any moment, each of our cells may contain hundreds of thousands of mRNA molecules, which they produce in order to make proteins of their own. Once those proteins are made, our cells then shred the mRNA with special enzymes. The mRNA molecules our cells make can only survive a matter of minutes. The mRNA in vaccines is engineered to withstand the cell’s enzymes a bit longer, so that the cells can make extra virus proteins and prompt a stronger immune response. But the mRNA can only last for a few days at most before they are destroyed.

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