People should stay away from vaping devices, the Centers for Disease Control and Prevention recommended Friday.

The CDC is currently investigating the spate of vaping-related illnesses that have popped up across the country in recent weeks. CDC officials are aware of 450 confirmed or suspected cases in 33 states.

“While this investigation is ongoing, people should consider not using e-cigarette products. People who do use e-cigarette products should monitor themselves for symptoms,” the CDC wrote in a news release.

The announcement comes on the same day that Indiana health officials confirmed the state’s first death from a vaping-related respiratory illness, bringing the national toll to three, after two such deaths in Illinois and in Oregon.

The CDC also said that it’s investigating a fourth death, but declined to say where.

Related: E-cigarettes and vaping

19 PHOTOSE-cigarettes and vapingSee GalleryE-cigarettes and vaping

Employee at Cloud 10, an e-cigarette store in Simi Valley, CA, demonstrates the type of smoke, with no smell, comes out of an electric cigarette. Sales are Booming at this store.

(Lynne Gilbert via Getty Images

A customer exhales vapor while smoking an electric cigarette at the Betamorph E-Cigs store in Albuquerque, New Mexico, U.S., on Saturday, Dec. 10, 2016. Sales in the U.S. vapor-device market are projected to rise by 21% annually through 2020, based on Euromonitor Passport data.

(Sergio Flores/Bloomberg via Getty Images)

An e-cigarette store in Simi Valley, CA, called Cloud 10, displays various types of electric cigarettes juice flavors for sale. Sales are Booming at this store.

(Lynne Gilbert via Getty Images)

Indonesian teenager exhaling smoke from Electric Cigarettes (e-cigarettes) as seen in Medan, North Sumatra, Indonesia on December 5, 2014 night. Electric cigarettes (e-cigarettes) are increasingly popular in Indonesia, especially among teenagers. In fact, cigarettes are actually more harmful than regular cigarettes with an increasing number of patients with poisoning after using electronic cigarettes and nicotine liquid continues to increase. The World Health Organization (WHO) notes, electronic cigarette brand has been produced in 466, 8,000 taste, spending budget of US $ 3 billion.

(Photo by Ivan Damanik/NurPhoto) 

Gdynia, Poland 29th, Dec. 2015 Polish Ministry of Health plans to ban electronic cigarettes sales to persons under the age of 18, restrictions on advertising and promotion and to introduce to them technical requirements. The new Tobacco Control law will come into force in the 2nd quarter of 2016. Pictured: Lady smokes electronic cigarette.

(Michal Fludra/Corbis via Getty Images)

Kiradech Aphibarnrat of Thailand smokes an electric cigarette during day two of the World Cup of Golf at Kingston Heath Golf Club on November 25, 2016 in Melbourne, Australia.

(Photo by Quinn Rooney/Getty Images)

Electric cigarette ‘juice’ w/various flavors.This is at Cloud 10 in Simi Valley, CA This brand is the most popular at this store. Santa Monica just passed the law no e-cigarettes allowed anywhere. Business is booming at this location.

(Lynne Gilbert via Getty Images

Mitchell Baker who works at the Vapour Place a vaping shop in Bedminster, exhales vapour produced by an e-cigarette on December 30, 2016 in Bristol, England. Recent figures released by the e-cigarette industry has claimed that there as many as 1700 vaping shops across the country, with two new ones opening each day catering for the estimated three million vapers in the UK. The popularity of e-cigarettes has boomed in the last ten years, as it is seen by many as a healthier alternative to traditional cigarettes, however some critics say the devices can carry the same risks as smoking especially as the long term affects are yet to be known.

(Matt Cardy/Getty Images)

E-cigarette merchandise is displayed for sale at the Vapour Place a vaping shop in Bedminster, on December 30, 2016 in Bristol, England. Recent figures released by the e-cigarette industry has claimed that there as many as 1700 vaping shops across the country, with two new ones opening each day catering for the estimated three million vapers in the UK. The popularity of e-cigarettes has boomed in the last ten years, as it is seen by many as a healthier alternative to traditional cigarettes, however some critics say the devices can carry the same risks as smoking especially as the long term affects are yet to be known.

(Photo by Matt Cardy/Getty Images)

A reveller dressed in a Father Christmas costume smokes from an electronic cigarette device as he takes part in Santacon outside Euston Station on December 10, 2016 in London, England. Santacon is an annual parade taking place in cities around the world and sees revellers dressed in Father Christmas costumes take to the streets to spread seasonal cheer.

(Photo by Jack Taylor/Getty Images)

Flavored vape juice bottles are displayed for sale at the Betamorph E-Cigs store in Albuquerque, New Mexico, U.S., on Saturday, Dec. 10, 2016. Sales in the U.S. vapor-device market are projected to rise by 21% annually through 2020, based on Euromonitor Passport data.

(Sergio Flores/Bloomberg via Getty Images)

A woman smokes an electronic cigarette during the Vapexpo 2015 Moscow, at Sokolniki Exhibition Center on December 05, 2015, in Moscow, Russia.

(Photo by Sefa Karacan/Anadolu Agency/Getty Images)

This picture taken on November 19, 2015 shows bottles of concentrated flavors displayed at a vape shop in Kuala Lumpur. Vaping’ is soaring in popularity in Malaysia, the largest e-cigarette market in the Asia-Pacific region, but authorities are threatening to ban the habit in for health reasons — a move that has sparked anger from growing legions of aficionados.

(MOHD RASFAN/AFP/Getty Images)

A man smokes an E-Cigarette in the Vape Lab coffee bar, on August 27, 2014 in London, England. The Department of Health have ruled out the outlawing of ‘e-cigs’ in enclosed spaces in England, despite calls by WHO, The World Health Organisation to do so. WHO have recommended a ban on indoor smoking of e-cigs as part of tougher regulation of products dangerous to children.

(Photo by Dan Kitwood/Getty Images)

This picture taken on November 19, 2015 shows a worker (R) inspecting a coil, the metal heating element in an e-cigarette that produces vapour from e-juices, at a vape shop in Kuala Lumpur. Vaping’ is soaring in popularity in Malaysia, the largest e-cigarette market in the Asia-Pacific region, but authorities are threatening to ban the habit in for health reasons — a move that has sparked anger from growing legions of aficionados.

(MOHD RASFAN/AFP/Getty Images)

A woman smokes an electronic cigarette during the Vapexpo 2015 Moscow, at Sokolniki Exhibition Center on December 05, 2015, in Moscow, Russia.

(Photo by Sefa Karacan/Anadolu Agency/Getty Images)

A customer smokes an E-Cigarette at Digital Ciggz on January 28, 2015 in San Rafael, California. The California Department of Public Health released a report today that calls E-Cigarettes a health threat and suggests that they should be regulated like regular cigarettes and tobacco products.

(Photo by Justin Sullivan/Getty Images)

E-Cigarettes are sold at the V-Revolution E-Cigarette shop in Covent Garden on August 27, 2014 in London, England. The Department of Health have ruled out the outlawing of ‘e-cigs’ in enclosed spaces in England, despite calls by WHO, The World Health Organisation to do so. WHO have recommended a ban on indoor smoking of e-cigs as part of tougher regulation of products dangerous to children.

(Photo by Dan Kitwood/Getty Images)

In this photo illustration, a man smokes an E-Cigarette at the V-Revolution E-Cigarette shop in Covent Garden on August 27, 2014 in London, England. The Department of Health have ruled out the outlawing of ‘e-cigs’ in enclosed spaces in England, despite calls by WHO, The World Health Organisation to do so. WHO have recommended a ban on indoor smoking of e-cigs as part of tougher regulation of products dangerous to children.

(Photo by Dan Kitwood/Getty Images)

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The person who died in Indiana was an adult, but officials gave no other details, citing privacy laws. There’s also no indication of what the person may have been vaping.

“The tragic loss of a Hoosier and rising number of vaping-related injuries are warnings that we cannot ignore,” Dr. Kris Box, Indiana’s health commissioner, said in a statement.

Neither federal nor state health investigators have been able to pinpoint a brand, ingredient or substance behind the illnesses, but many suspect oils in vapes may play a role.

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