The younger brother of an NFL star has been stabbed to death outside a pub.

Clayton Beathard, 22, died of multiple injuries in the attack, said to have happened after an argument in the early hours of Saturday morning.

Another man, 21-year-old Paul Trapeni III, was also killed in the altercation outside Dogwood Bar in Nashville, Tennessee.

Police have launched a manhunt to find the killer.

They say there were several witnesses to the horror and have released CCTV of people they hope to talk to in the wake of the tragedy.

The stabbings "appear to have resulted from an argument over a woman that began inside Dogwood Bar and then turned physical when the parties went outside," officers added.

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Multiple people were involved in the initial row, it is thought, and a third young man was also stabbed.

The 21-year-old man suffered wounds to his eye and arm and remains in hospital.

Clayton is the brother of C.J. Beathard, who plays as quarter back for the San Francisco 49ers.

The Beathard family released a statement expressing their distress. 

"It’s times like this I wish had Instagram and social media because the love and prayers have been so overwhelming. We cannot possibly thank you at the rate they come in texts and phone calls," the statement said.

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"Clay was an amazing, big and soft-hearted human being with an undeniable love for the Lord. He had his family's, friends' and teammates' backs even to a fault. I wish he would have been more inclined to take the high road but he hated "wrong."

"Yes, he was stubborn sometimes but mostly because his beliefs were strong. He lived a full life except for the chance at being the incredible father I knew he would have been. He loved kids, underdogs and the less fortunate.

"His little sister was his world and his love and pride for his older brothers was off the charts. He will be missed. That is an understatement. Nobody's light shined like his when he smiled."

C.J. Beathard, 26, missed San Francisco 49ers' game on Saturday as he was with family.

His head coach Kyle Shanahan was filmed addressing his team with a heartfelt speech in which he urged them to "win for Beathard".

They did just that and overcame the Los Angeles Rams 34-31 at the Levi's Stadium.

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