Lilly Updates On Jardiance Exercise Ability Studies In Chronic Heart Failure

Boehringer Ingelheim and Eli Lilly and Co. (LLY), in an update on Jardiance phase III exercise ability studies in chronic heart failure, said that there was no significant change from baseline to week 12 in exercise ability with Jardiance versus placebo, as measured by the six-minute walk test, which was the primary endpoint of the studies.

The safety profile seen in the EMPERIAL trials was similar to the currently known safety profile of Jardiance and no new safety risks were identified.

The EMPERIAL trials, which included people with and without diabetes, deliver novel safety data for Jardiance in non-diabetic patients with heart failure.

In addition, EMPERIAL-Preserved is the first trial to deliver safety data for Jardiance in heart failure with preserved ejection fraction.

The EMPERIAL studies were initiated based on data obtained from the EMPA-REG OUTCOME® trial, in which Jardiance showed a 38% relative risk reduction in cardiovascular death and a 35% relative risk reduction in hospitalization for heart failure in adults with type 2 diabetes and established cardiovascular disease, compared to placebo.

France's Macron wants 'very special relationship' with Britain after Brexit

PARIS (Reuters) – French President Emmanuel Macron said on Friday he wanted a “very special relationship” with Britain after it leaves the European Union, saying Brexit doesn’t mean Britain is leaving Europe altogether.

“I want to tell our British friends and allies… you are not leaving Europe,” Macron told a news conference in Brussels, adding that he wanted a close relationship to be built with Britain, especially in defense and security.

Boots UK to stock Mothercare products

Dec 13 (Reuters) – Mothercare Plc said on Friday Boots UK, owned by U.S.-based Walgreens Boots Alliance, will become its new exclusive franchisee partner and stock the struggling retailer’s brand of clothing, home and travel products.

Mothercare, which had appointed administrators for its UK business, said the partnership will initially be for five years, with terms and royalty rates arrangements broadly in line with its existing franchisee agreements. (Reporting by Tanishaa Nadkar in Bengaluru; Editing by Maju Samuel)

From 'vindication' to 'meltdown,' here are how UK newspapers are announcing Boris Johnson's landslide election win

• Polls have closed in the UK general election, and exit polls suggest the Tories will win 368 seats, compared to Labour's 191.
• The final tally is expected by 6:00 a.m. on Friday morning, according to the BBC. 
• This marks a huge victory for Boris Johnson, who leads the Conservative party, ahead of a fast-approaching Brexit deadline which has been extended by the EU to January 31, 2020.
• Check back for updates as more election results and front pages roll in.
• Visit Business Insider's home page for more stories. 

Polls have closed in the UK general election, and exit polls suggest Prime Minister Boris Johnson's Conservative party will win 368 seats, compared to Labour's 191.

This marks a huge victory for Johnson, who leads the Conservative party, ahead of a fast-approaching Brexit deadline which has been extended by the EU to January 31, 2020. 

The final tally is expected by 6:00 a.m. on Friday morning, according to the BBC. 

Here are how major newspapers in the UK are announcing the election results. 

Metro UK:

The Telegraph:

The Daily Mirror:

The Sun:

Daily Mail:

Daily Express:

The Times:

I:

The Guardian:

Canada Q3 household debt-to-income ratio rises

TORONTO, Dec 13 (Reuters) – The ratio of Canadian household debt-to-income widened to 174.0% in the third quarter from a downwardly revised 173.4% in the second quarter, Statistics Canada said on Friday.

National net worth rose by 0.1% in the third quarter to C$12.62 trillion ($9.59 trillion), while national net worth decreased to C$334,165 on a per capita basis.

House Judiciary Committee approves articles of impeachment against Trump

The Democratic-led House Judiciary Committee on Friday approved two articles of impeachment against President Donald Trump. The articles charge Trump with abuse of power and obstructing Congress, and next head to the House floor, where a vote is likely sometime next week. A trial in the Republican-controlled Senate is expected in January. Trump has denied any wrongdoing as Democrats seek to impeach him. The panel’s votes were 23-17 and along party lines, with no Republicans approving the articles.

U.S. Wholesale Inventories Inch Up Less Than Expected In October

Wholesale inventories in the U.S. crept up by slightly less than expected in the month of October, according to a report released by the Commerce Department on Friday.

The Commerce Department said wholesale inventories inched up by 0.1 percent in October after falling by a revised 0.7 percent in September.

Economists had expected inventories to rise by 0.2 percent compared to the 0.4 percent drop originally reported for the previous month.

Inventories of non-durable goods climbed by 0.7 percent in October after tumbling by 1.3 percent in September, but inventories of durable goods fell by 0.3 percent for the second straight month.

Meanwhile, the report said wholesale sales slid by 0.7 percent in October after edging down by 0.1 percent in September.

The continued decrease in wholesale sales came as sales of durable goods fell by 0.6 percent and sales of non-durable goods slumped by 0.9 percent.

With inventories rising and sales falling, the inventories/sales ratio for merchant wholesalers ticked up to 1.37 in October from 1.36 in September.